PUBLICATIONS
BMP Promotes Motility and Represses Growth of Smooth Muscle Cells by Activation of Tandem Wnt Pathways. de Jesus Perez VA, Ali z. Alastalo TP, Ikeno F, Sawada H, Lai Yj, Kleisli T, Spiekerkoetter E, Qu X, Rubinos LH, Ashley E, Amieva M, Dedhar S, Rabinovitch M. J Cell Biol 2011; 192:171-188 This article is featured in biobytes podcast, http://jcb.rupress.org/content/192/1/171/suppl/DC2
Genomics and Proteomics of Pulmonary Vascular Disease. Geraci M, Meyrick B. Compr Physiol 1:467-483, 2011
Hypoxia inducible-factor 1 alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells. Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM. Am J Pathol. 2010 Mar;176(3):1130-8. PMID 20110409 [PMCID in process]
Ventricular geometry, strain and rotational mechanics in pulmonary hypertension. Circulation. Puwanant S, Park M, Popović ZB, Tang WH, Farha S, George D, Sharp J, Puntawangkoon J, Loyd JE, Erzurum SC, Thomas JD. 2010 Jan 19;121(2):259-66. PMID 20048214 [PMCID in process]
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Am J Physiol Lung Cell Mol Physiol. 2009;297(6):L1013-32. Epub 2009 Sep 11. Review.
T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO. Respir Med. Respir Med. 2010 Mar;104(3):454-62 Epub 2009 Oct 30.
Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension. Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SAA, Xu W, Licina L, Tuder RM, Erzurum SC (2008). AM J PATH. Mar;172(3):615-27.
High Levels of Hyaluronan In Idiopathic Pulmonary Arterial Hypertension. Aytekin M, Comhair SA, de la Motte C, Bandyopadhyay SK, Farver VC, Erzurum SC, Dweik RA (2008). AM J PHYSIOL LUNG CELL MOL PHYSIOL. Sep 5;295: L789-99.
Deficiency of Lung Antioxidants in Idiopathic Pulmonary Arterial Hypertension. Masri FA, Comhair SAA, Dostanic-Larson I, Kaneko FT, Dweik RA, Arroliga AC, Erzurum SC (2008). CLIN TRANSL SCI. 1: 99-100.
Proteomics of transformed lymphocytes from a family with familial pulmonary arterial hypertension. Meyrick BO, Friedman DB, Billheimer DD, Cogan JD, Prince MA, Phillips JA, Loyd JE (2008). Am J Respir Crit Care Med. 1;177:99-107.
Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance. West J, Cogan J, Geraci M, Robinson L, Newman J, Phillips JA, Lane K, Meyrick B, Loyd J (2008). BMC Med Genomics Sep 29;1:45.
PUBLICATIONS SUBMITTED
Neutrophil Elastase is Produced by Pulmonary Artery Smooth Muscle Cells and is Linked to Neointimal Lesions. Kim Y, Haghighat L, Spiekerkoetter E, Sawada H, Alvira C, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, and Rabinovitch M.
American Journal of Pathology, 2011 (Accepted)
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, Sokol RJ, Strassheim D, Meyrick B, Yeager ME, Flockton AR, B. McKeon A, Lemon DD, Horn TR, Anwar A, Barajas C, Stenmark KR. Submitted for publication, in revision, 2011
Bone Morphogenetic Protein Induces a PPARCatenin Transcription Factor Complex Targeting Apelin to Prevent Pulmonary Hypertension. Alastalo, T-P, Molong L, de Jesus Perez V, Pham D, Sawada H, Wang JK, Kosenvuo M, Wang L, Chang HY, and Rabinovitch M. Journal of Clinical Investigation 2011, in press.
Reduced BMPR-II Induces GM-CSF Translation and Macrophage Recruitment in Humans and Mice, Exacerbating Pulmonary Hypertension. Sawada H, Alastalo T-P, Glotzbach JP, Chan R, Fuchs G, Januszyk M, Lai Y-J, de Jesus Perez V, Kim Y, Wang L, Saito T, Spiekerhoetter E, Gurtner CG, Sarnow P, Rabinovitch M. Under review.
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ABSTRACTS
(Presentation where noted)
FK-506 (Tacrolimus), identified in a High Throughput Screen to Increase BMPRII Signaling, Prevents Pulmonary Arterial Hypertension (PAH) in Mice with Endothelial BMPRII Deletion (#B16) Edda Spiekerkoetter, Leila Haghighat, Roxanna Haghighat, Hirofumi Sawada, Toshie Saito, Lingli Wang, Vinicio de Jesus Perez, Peter ten Dijke, Nesrine El-Bizri, David Solow-Cordero, Philip A. Beachy, and Marlene Rabinovitch. Abstract published in: Am. J. Respir. Crit. Care Med., May 2011; 183: A2519
Heterozygous Mutations in the Adenomatous Poliposis Coli (Apc) Gene Promote Development Of Pulmonary Hypertension By Reducing Pulmonary Endothelial Cell Adhesion And Survival (Poster #C61) vinicio de Jesus Perez, Hirofumi Sawada, Roop Dutta, Edda Spiekerkoetter, Lingli Wang, and Marlene Rabinovitch. Abstract published in: Am. J. Respir. Crit. Care Med., May 2011; 183: A4963
Cellular physiology and pathology in idiopathic PAH: relationship with genetic abnormalities. President’s Symposium Talk - Physiology InFocus Marlene Rabinovitch. The American Physiological Society - Experimental Biology Meeting, Washington, DC (April 9-13, 2011)
Cellular and Molecular Mechanisms of Pulmonary Vascular Dysfunction. Marlene Rabinovitch, MD, Featured Speaker presentation. American Thoracic Society (ATS) International Conference in Denver, Colorado (May 15-18, 2011)
Histology-directed mass spectroscopy reveals alterations in localization and expression of histone 1 (H1) in pulmonary arteries from IPAH lungs versus controls. Meyrick B, Seeley E, Ye F, Zhang X, Talati M, Shyr Y, Caprioli R. Am J Respir Crit Care Med Am J Respir Crit Care Med May 2011
Bone Morphogenetic Protein Recruits a Peroxisome Proliferator-Activated Receptor and β-catenin Transcription Factor Complex to Regulate Apelin Expression in Pulmonary Endothelial Cells. Tero-Pekka Alastalo; Molong Li; Vinicio de Jesus Perez; Hirofumi Sawada; Marlene Rabinovitch. Abstract 5317: Circulation. 2009;120:S1083
GM-CSF Mediated Proinflammatory State in Pulmonary Vascular Cells Enhanced by Reduced BMPR-II and Its Association With Vascular Lesions in Idiopathic Pulmonary Arterial Hypertension. Hirofumi Sawada; Tero-Pekka Alastalo; Vinicio de Jesus Perez; Lingli Wang; Marlene Rabinovitch. Abstract 3462: Circulation. 2009;120:S804.
Bone Morphogenetic Protein Recruits a Peroxisome Proliferator-Activated Receptor Gamma and Beta-Catenin Complex to Regulate Apelin Expression in Pulmonary Endothelial Cells. T. Alastalo, M. Li, D. Pham, V. de Jesus Perez, H. Sawada, M. Rabinovitch, M. Rabinovitch. Abstract 952/B011: American Society of Cell Biology, 49th Annual meeting
Bone Morphogenetic Protein Promotes Motility and Represses Proliferation of Vascular Smooth Muscle Cells by Tandem Recruitment of Canonical and Non-canonical Wnt Signaling Pathways (Poster # 710) V. de Jesus Perez, Z. Ali, T-P. Alastalo, H. Sawada, J. Axelrod, E. Ashley, M. Rabinovitch. Abstract published in: Am J Respir Crit Care Med 181;2010:A1179
Micro RNA 21 (miR-21) is a regulator of Bone Morphogenetic Protein Receptor II in patients with pulmonary hypertension (Poster #303) E. Spiekerkoetter, T.-P. Alastalo, H. Sawada, Y-M. Kim, V. de Jesus Perez, L. Wang, M. Rabinovitch Abstract published in: Am J Respir Crit Care Med 181;2010:A5226
GMCSF Translation is Enhanced by Reduced BMPRII and is Increased in Pulmonary Arteries of IPAH Patients (#2742/L68) Hirofumi Sawada, TeroPekka Alastalo, Vinicio de Jesus Perez, Lingli Wang and Marlene Rabinovitch.
Neutrophil elastase is a novel endogenous vascular elastase expressed in pulmonary artery smooth muscle cells contributing to pulmonary vascular disease in S100A4 overexpressing mice infected with murine gamma hespresvirus68 (B404) YuMee Kim, Leila Haghighat, Edda Spiekerkoetter, Lingli Wang, and Marlene Rabinovitch.
Neutrophil elastase is the endogenous vascular elastase (EVE) produced by pulmonary artery smooth muscle cells in clinical and experimental pulmonary vascular disease (Mini symposium oral presentation) Y-M. Kim, H. Sawada, C.M. Alvira, E. Spiekerkoetter, L. Wang, M. Rabinovitch. Abstract published in: Am J Respir Crit Care Med 181;2010:A4023
The position of BMPR2 mutation in patients with PAH affects protein expression in EBV transformed lymphocytes. Meyrick BO, Friedman DB, Cogan JD, Wheeler L, Loyd JE. Am J Respir Clin Care Med 179: 349, 2009. Platform presentation.
Mutated BMPR2 downregulates expression of ETA and ETB receptors in lung macrophages. Talati M, West J, Meyrick B. Am J Respir Clin Care Med 179:400, 2009. Poster presentation.
Amhara Highlanders In Ethiopia Elevate Pulmonary Artery Pressure And Blood Flow But Not Resistance. Beall CM, Hoit BD, Dalton ND, Gebremedhin A, Janocha A, Zimmerman PA, Zimmerman AM, Strohl KP and Erzurum SC. Hypoxia Proceedings (in press). Paper presented at Hypoxia XVI: Hypoxia and Exercise, March 10-15, 2009 at Chateau Lake Louise, Alberta, Canada
Effect of MnSOD on HIF Activation in Endothelial Cells from PAH Lungs. W. Xu, MD, I. Fijalkowska, PhD, S.A.A. Comhair, PhD, A.J. Janocha, BS, L.A. Mavrakis, BA, R.M. Tuder, MD, S.C. Erzurum, MD. Proc Am Thoracic Soc. 2009; A5121
Acquired Genetic Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension. M.A. Aldred, PhD, S.A.A. Comhair, PhD, M.V. Garcia, PhD, W. Xu, PhD, K. Asosingh, PhD, G.P. Noon, MD, P.A. Thistlethwaite, MD PhD, R.M. Tuder, MD, S.C. Erzurum, MD, M.W. Geraci, MD, C.D. Coldren, PhD. Proc Am Thoracic Soc. 2009; A6010
Erythropoietin: Biomarker of Pulmonary Hypertension. S. Farha, MD, K. Asosingh, PhD, J. Sharp, CNP, D. George, MD, M.A. Aldred, PhD, R. Steinle, MS, E. Hsi, MD, K. Theil, MD, A. Lichtin, MD, J.E. Loyd, MD, M. Park, RVT, RDC, W. Tang, MD, J. Thomas, MD, S.C. Erzurum, MD. Proc Am Thoracic Soc. 2009; A2662
Abnormal Transpulmonary Metabolite Flux in Exercise Induced Pulmonary Arterial Hypertension. P. Troy, MD, G. Lewis, MD, A.J. Janocha, BSE, T. Van Horn, BA, S.C. Erzurum, MD, A.B. Waxman, MD, PhD, D.M. Systrom, MD. Proc Am Thoracic Soc. 2009; A4131
Human Lung Microvascular Endothelial Cells in Pulmonary Arterial Hypertension. Comhair SAA, Mavrakis L, Xu W, Asosingh K, Erzurum SC (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A1853.
Recent rise in the Incidence of Pneumocystis Jirovecii Pneumonia in Heart and Lung Transplant Recipients beyond the Standard Prophylaxis Interval. Fulton JC, Hajari AS, Barney J, Tallaj JA, Pamboukian S, Gaggar A, Leon K, DeAndrade J, Pajaro OE, McGiffin DC, Young KR, Wille KM (2009 May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: 4591.
Systematic collection of human pulmonary arterial hypertension lung tissue: Methods of the Pulmonary Hypertension Breakthrough Initiative (PHBI). McLaughlin V, Eu J, Everett A, Grizzle W, Jones P, Tuder R, Geraci M on behalf of the PHBI Investigators (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A3362.
The Position of BMPR2 Mutation in Patients with FPAH Affects Protein Expression in EBV Transformed Lymphocytes. Meyrick B, Friedman DB, Cogan J, Wheeler L, Loyd JE (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A5119.
Effect of Genetic Variations in the GPCR subunits on Cell Signaling in IPAH Patients. Olave NC, Benza RL, Grenett HE (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A5054.
Histopathological assessment of the first 9 cases collected by the Pulmonary Hypertension Breakthrough Initiative (PHBI). Tuder RM, Sexton KC, Zhang L, Watkins J, Parker SB, Grizzle WE (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A4881.
Differences in Lymphocyte Surface Nucleotidases in Patients with Pulmonary Hypertension. Visovatti SH, Djergovic D, Hyman MC, Rubenfire M, McLaughlin V, Pinsky DJ (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A2351.
Increased CD39 Expression on Circulating Platelet Microparticles in Patients with Primary Pulmonary Hypertension. Visovatti SH, Hawley A, Hyman MC, Rubenfire M, Myers D, Wakefield TW, McLaughlin V, Pinsky DJ (2009, May). Presented at the International Conference of the American Thoracic Society, San Diego, CA. Am J Respir Crit Care Med 179 April: A4907.
Increased levels of hyperproliferative and invasive bone marrow-derived CD34+CD133+ angiogenic progenitors in idiopathic pulmonary arterial hypertension. Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SAA, Xu W, Licina L, Huang L, Anand-Apte B, Yoder MC, Tuder RM, Erzurum SC (2008, May) Presented at the International Conference of the American Thoracic Society, Toronto, ON, Canada. Am J Respir Crit Care Med 177 April: A771.
Angiogenic progenitor cells in familial pulmonary arterial hypertension. Farha SY, Asosingh K, Aldred M, Sharp J, Lichtin A, Lloyd J, Erzurum SC (2008, May). Presented at the International Conference of the American Thoracic Society, Toronto, ON, Canada. Am J Respir Crit Care Med 177 April: A534.
Proteomic profiles of transformed lymphocytes from patients with idiopathic pulmonary arterial hypertension differ from controls. Meyrick B, Friedman DB, Cogan JD, Wheeler L, Phillips JA III, Loyd JE (2008, May). Presented at the International Conference of the American Thoracic Society, Toronto, ON, Canada. Am J Respir Crit Care Med 177 April: A288.
Lymphocyte analyses of the blood and lungs in Idiopathic Pulmonary Arterial Hypertension (IPAH). E.D. Austin ED, Rock MT, Vnencak-Jones CL, Yoder SM, Zhu T, Robbins I, Loyd JE, Meyrick BO. Am J Respir Crit Care Med 177:A261, 2008.
Decreased 5'-nucleotidase (CD73) on T lymphocytes of patients with idiopathic pulmonary arterial hypertension. Visovatti SH, Hyman MC, Rubenfire M, Yanamadala S, Petrovic-Djergovic D, Pinsky DJ (2008, November). Presented at the American Heart Association Scientific Sessions, New Orleans, LA.
Hypoxia Response in Pulmonary Hypertension arterial Endothelial Cells. Xu W, Koeck T, Koo M, Comhair SAA, Jennings C, Dweik RA, Fijalkowska I, Tuder RM, Stueher DJ, Erzurum SC (2008, May). Presented at the International Conference of the American Thoracic Society, Toronto, ON, Canada. Am J Respir Crit Care Med 177 April: A251.
Idiopathic Pulmonary Arterial Hypertension Is Associated with Reduction in Superoxide Dismutase. Dostanic-Larson I, Ricci KS, Erzurum SC, Comhair SAA (2007, May). Presented at the International Conference of the American Thoracic Society, San Francisco, CA. Am J Respir Crit Care Med 175 April: A409.
Proteomic Differences in Transformed Lymphocytes from Family Members with a BMPR2 Mutation with and without Evidence of Familial Pulmonary Arterial Hypertension. Meyrick B (2007, May). Presented at the International Conference of the American Thoracic Society, San Francisco, CA. Am J Respir Crit Care Med 175 April: A557.
Assessing signal to noise in quantitative proteomics. Friedman, D.B., Whitwell, C.W., Loyd, J.E., Meyrick, B. J Biomol Tech. 18:180, 2007
Increased CD39 Nucleotidase Activity on Microparticles from Patients with Idiopathic Pulmonary Arterial Hypertension. Visovatti SH, Hyman MC, Bouis D, Neubig R, McLaughlin VV, et al. (2012) PLoS ONE 7(7): e40829. doi:10.1371/journal.pone.0040829 http://www.ncbi.nlm.nih.gov/pubmed/22792409
ABSTRACTS SUBMITTED
None available at this time
PRESENTATIONS
”Proteomic analysis of transformed lymphocytes from patients with familial and idiopathic pulmonary arterial hypertension”. Meyrick B (November, 2009) Invited Speaker, American Heart Association, Orlando, FL.
“The changing pathology of pulmonary arterial hypertension”.
Meyrick B (September 2009). Visiting Professor, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
Proteomics in Pulmonary Arterial Hypertension. Meyrick B (2008, November). Presented at the American Heart Association Scientific Sessions, New Orleans, LA.
PRESENTATIONS SUBMITTED
None available at this time
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